D.K. Livkon

Introduction to Oral Thin Films Or Orally Disintegrating Strips

Oral Thin Films (OTFs) are a relatively new drug delivery technology that has gained popularity due to its ability to overcome the taste barrier. OTFs are a type of drug delivery system that consists of a thin, flexible strip that dissolves on the tongue and delivers the medication directly into the bloodstream. Unlike traditional oral medications, which can have an unpleasant taste or require swallowing, OTFs offer a more patient-friendly experience.

Benefits of Oral Thin Films

OTFs offer several benefits over traditional oral medications. For one, they are more convenient for patients who have difficulty swallowing pills or capsules. Additionally, they dissolve quickly in the mouth, allowing for faster absorption and quicker onset of action. This is particularly important for medications that are used to treat acute conditions or provide rapid relief from symptoms.

OTFs are also a more discreet way to take medication, which can be important for patients who may be self-conscious about taking medication in public or at work. The thin, flexible strips are easy to carry in a purse or pocket and can be taken without water, making them ideal for people on the go.

Overcoming the Taste Barrier

One of the most significant advantages of OTFs is their ability to overcome the taste barrier. Many medications have an unpleasant taste that can make them difficult to swallow, especially for children or patients with certain medical conditions. OTFs, on the other hand, can be formulated to taste better or even mask the taste of the medication altogether.

The taste-masking technology used in OTFs involves the use of sweeteners, flavors, and other ingredients that can help to improve the taste of medications. Some OTFs are also designed to dissolve more slowly, which can help to reduce the bitterness or aftertaste of the medication.

Examples of Oral Thin Films

OTFs are currently available for a variety of medications, including anti-allergy drugs, antiemetics, and analgesics. One example of an OTF medication is Zuplenz, which is used to treat nausea and vomiting caused by chemotherapy or radiation therapy. Zuplenz contains ondansetron, an antiemetic drug that is delivered through an OTF strip that dissolves on the tongue.

Another example of an OTF medication is Suboxone, which is used to treat opioid dependence. Suboxone contains buprenorphine and naloxone and is delivered through a sublingual film that dissolves under the tongue. Suboxone is an excellent example of how OTFs can be used to improve patient experience, as the medication is much easier to take than traditional opioid replacement therapies, which are often administered through injections or nasal sprays.


Oral Thin Films offer several advantages over traditional oral medications, including faster absorption, convenience, and the ability to overcome the taste barrier. These benefits can improve patient experience and make medication easier to take. As more medications become available in OTF form, patients will have more options for how they take their medication and will be able to choose the most convenient and comfortable method for their individual needs.


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