D.K. Livkon

The Art and Science of Orally Disintegrating Strip Manufacturing


Orally disintegrating strips (ODS) have revolutionized drug delivery, offering a convenient and efficient way to administer medication without the need for water or swallowing. But what goes on behind the scenes in the manufacturing of these innovative pharmaceutical products? Let’s dive into the art and science of ODS manufacturing to uncover the intricate processes involved.

Understanding Orally Disintegrating Strips:

Orally disintegrating strips, also known as orally dissolving films, are thin, flexible strips containing active pharmaceutical ingredients (APIs) that dissolve quickly when placed on the tongue. These strips provide a convenient alternative to traditional dosage forms like tablets and capsules, particularly for patients who have difficulty swallowing or are on the go.

Formulation Development:

The journey of an ODS begins with formulation development, where scientists meticulously select ingredients and optimize their ratios to ensure proper drug delivery and rapid disintegration. Key factors considered during this stage include the choice of film-forming polymers, plasticizers, APIs, flavoring agents, and disintegrants. Orally Disintegrating Strips Manufacturers: Leading pharmaceutical companies across the globe invest in state-of-the-art facilities and cutting-edge technology to produce orally disintegrating strips, ensuring precise formulation, manufacturing, and packaging processes.

Film Casting:

Once the formulation is finalized, the next step is film casting. This process involves spreading the liquid formulation onto a flat surface and allowing it to dry to form a thin film. Precise control of drying conditions, such as temperature and humidity, is crucial to ensure uniform thickness and quality of the film.

Printing and Cutting:

After the film is dried, it undergoes printing and cutting processes to create individual strips. Printing may involve applying dosage information, branding, or other markings onto the film surface. Precision cutting equipment is then used to slice the continuous film into individual strip units of the desired size.


Packaging plays a crucial role in preserving the integrity and stability of ODS products. Individual strips are typically packaged in foil pouches or blister packs to protect them from moisture, light, and other environmental factors. Proper sealing techniques are employed to maintain product freshness and extend shelf life.

Quality Control:

Throughout the manufacturing process, stringent quality control measures are implemented to ensure the safety, efficacy, and consistency of ODS products. This includes testing raw materials, in-process samples, and finished products for various parameters such as uniformity, dissolution rate, content uniformity, and microbial contamination.

Regulatory Compliance:

Manufacturers of ODS must adhere to strict regulatory guidelines set forth by health authorities such as the FDA and EMA. Compliance with Good Manufacturing Practices (GMP) is essential to ensure product quality, safety, and efficacy. Regulatory submissions may also be required for approval of new ODS formulations or modifications to existing ones. Oro Dispersible Film manufacturers like DK Kivkon leverage the city’s infrastructure and expertise to develop and produce high-quality orally disintegrating strips, adhering to stringent regulatory standards.


The manufacturing of orally disintegrating strips involves a blend of art and science, from formulation development to packaging and regulatory compliance. By harnessing innovative technologies and adhering to rigorous quality standards, manufacturers can produce high-quality ODS products that offer patients a convenient and effective alternative to traditional dosage forms.

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